A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer

Yaron Vinik; Sima Lev

doi:10.1038/s41419-024-06766-8

A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer

Yaron Vinik, Sima Lev^*

^*Corresponding author for this work

Department of Molecular Cell Biology

Research output: Contribution to journal › Comment/debate › peer-review

4 Citations (Scopus)

Abstract

Apoptosis and ferroptosis are two regulated cell death (RCD) pathways implicated in different human diseases and considered as promising strategies to eliminate cancer cells. These two pathways are characterized by distinct morphological and biochemical properties, induce cell death through different mechanisms, but share common regulators in different cancer types. Although apoptosis and ferroptosis have been extensively studied over the last few years, their transcriptomic responses have not yet been systematically compared due to remarkable variability in the transcriptomic data. Here we provide a brief snapshot of the transcriptomic landscapes of the apoptosis and ferroptosis responses in cancer, discuss their divergent and convergent properties, and implications to cancer therapy.

Original language	English
Article number	371
Number of pages	4
Journal	Cell Death and Disease
Volume	15
DOIs	https://doi.org/10.1038/s41419-024-06766-8
Publication status	Published - 29 May 2024

Funding

S.L. is the incumbent of the Joyce and Ben B. Eisenberg Chair of Molecular Endocrinology and Cancer Research. This work is supported by the Cooperation Program in Cancer Research of the Deutsches Krebsforschungszentrum (DKFZ) and Israel’s Ministry of Innovation, Science and Technology (MOST), the Israel Science Foundation (grant 1564/23), by a research grant from the Erica Drake Fund and from Louis J. Lavigne and Nancy Rothman, the Estate of Celina Bojarsky, and Robert N. and Judith Snyder. Publisher Copyright: © The Author(s) 2024.

All Science Journal Classification (ASJC) codes

Immunology
Cellular and Molecular Neuroscience
Cell Biology
Cancer Research

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abstract = "Apoptosis and ferroptosis are two regulated cell death (RCD) pathways implicated in different human diseases and considered as promising strategies to eliminate cancer cells. These two pathways are characterized by distinct morphological and biochemical properties, induce cell death through different mechanisms, but share common regulators in different cancer types. Although apoptosis and ferroptosis have been extensively studied over the last few years, their transcriptomic responses have not yet been systematically compared due to remarkable variability in the transcriptomic data. Here we provide a brief snapshot of the transcriptomic landscapes of the apoptosis and ferroptosis responses in cancer, discuss their divergent and convergent properties, and implications to cancer therapy.",

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AU - Lev, Sima

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AB - Apoptosis and ferroptosis are two regulated cell death (RCD) pathways implicated in different human diseases and considered as promising strategies to eliminate cancer cells. These two pathways are characterized by distinct morphological and biochemical properties, induce cell death through different mechanisms, but share common regulators in different cancer types. Although apoptosis and ferroptosis have been extensively studied over the last few years, their transcriptomic responses have not yet been systematically compared due to remarkable variability in the transcriptomic data. Here we provide a brief snapshot of the transcriptomic landscapes of the apoptosis and ferroptosis responses in cancer, discuss their divergent and convergent properties, and implications to cancer therapy.

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ER -

A snapshot into the transcriptomic landscape of apoptosis and ferroptosis in cancer

Abstract

Funding

All Science Journal Classification (ASJC) codes

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