Abstract
During evolution, novel phenotypes emerge through changes in gene expression, but the genetic basis is poorly understood. We compared the allele-specific expression of two yeast species and their hybrid, which allowed us to distinguish changes in regulatory sequences of the gene itself (cis) from changes in upstream regulatory factors (trans). Expression divergence between species was generally due to changes in cis. Divergence in trans reflected a differential response to the environment and explained the tendency of certain genes to diverge rapidly. Hybrid-specific expression, deviating from the parental range, occurred through novel cis-trans interactions or, more often, through modified trans regulation associated with environmental sensing. These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization.
| Original language | English |
|---|---|
| Pages (from-to) | 659-662 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 324 |
| Issue number | 5927 |
| DOIs | |
| Publication status | Published - 1 May 2009 |
Funding
Helen and Martin Kimmel Award for Innovative Investigations; Kahn Fund for Systems Biology at the Weizmann Institute of Science; Israeli Ministry of Science; Bi-national Science Foundation; European Research CouncilWe thank J. Berman, Y. Eshed, N. Sigal, A. Sheperberg, and members of our groups for discussions and comments. This work was supported by the Helen and Martin Kimmel Award for Innovative Investigations and grants from the Kahn Fund for Systems Biology at the Weizmann Institute of Science, the Israeli Ministry of Science, the Bi-national Science Foundation, and the European Research Council (Ideas) (to N.B). A.A.L. holds the Gilbert de Botton chair of Plant Science. Microarray data has been deposited at the Gene Expression Omnibus with accession number GSE14708 [NCBI GEO] .
All Science Journal Classification (ASJC) codes
- General