Aberrant nuclei with amplified DNA in cancer

Venkata Narasimha Kadali; Ofer Shoshani

doi:10.1016/j.trecan.2024.09.005

Aberrant nuclei with amplified DNA in cancer

Venkata Narasimha Kadali, Ofer Shoshani^*

^*Corresponding author for this work

Department of Biomolecular Sciences

Research output: Contribution to journal › Short survey › peer-review

Abstract

Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.

Original language	English
Pages (from-to)	9-11
Number of pages	3
Journal	Trends in Cancer
Volume	11
Issue number	1
Early online date	6 Oct 2024
DOIs	https://doi.org/10.1016/j.trecan.2024.09.005
Publication status	Published - Jan 2025

Funding

O.S. is supported by the following research grants: Israel Science Foundation (grant number 686/22), Dr Barry Sherman Institute for Medicinal Chemistry, Minerva Stiftung - Research Grant (grant number 146552), Moross Integrated Cancer Center, Flight Attendant Medical Research Institute, Florida, Kekst Family Institute for Medical Genetics at The Weizmann Institute of Science, and the Center for New Scientists at the Weizmann Institute of Science.

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1016/j.trecan.2024.09.005

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title = "Aberrant nuclei with amplified DNA in cancer",

abstract = "Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.",

author = "Kadali, {Venkata Narasimha} and Ofer Shoshani",

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year = "2025",

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language = "English",

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AU - Kadali, Venkata Narasimha

AU - Shoshani, Ofer

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N2 - Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.

AB - Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.

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U2 - 10.1016/j.trecan.2024.09.005

DO - 10.1016/j.trecan.2024.09.005

M3 - Short survey

AN - SCOPUS:85205514373

SN - 2405-8033

VL - 11

SP - 9

EP - 11

JO - Trends in Cancer

JF - Trends in Cancer

IS - 1

ER -

Aberrant nuclei with amplified DNA in cancer

Abstract

Funding

All Science Journal Classification (ASJC) codes

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