TY - JOUR
T1 - Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain
AU - Zigdon, Hila
AU - Kogot-Levin, Aviram
AU - Park, Joo-Won
AU - Goldschmidt, Ruth
AU - Kelly, Samuel
AU - Merrill, Alfred H., Jr.
AU - Scherz, Avigdor
AU - Pewzner-Jung, Yael
AU - Saada, Ann
AU - Futerman, Anthony H.
PY - 2013/2/15
Y1 - 2013/2/15
N2 - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.
AB - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.
UR - http://www.scopus.com/inward/record.url?scp=84874086182&partnerID=8YFLogxK
U2 - 10.1074/jbc.M112.402719
DO - 10.1074/jbc.M112.402719
M3 - Article
SN - 0021-9258
VL - 288
SP - 4947
EP - 4956
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 7
ER -