Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Muhammad Nawaz Tahir; Ruben Ragg; Filipe Natalio; Jugal Kishore Sahoo; Phillip Daniel; Kaloian Koynov; Dennis Strand; Susanne Strand; Wolfgang Tremel

doi:10.1039/c4tb01959h

Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Muhammad Nawaz Tahir, Ruben Ragg, Filipe Natalio, Jugal Kishore Sahoo, Phillip Daniel, Kaloian Koynov, Dennis Strand, Susanne Strand, Wolfgang Tremel^*

^*Corresponding author for this work

Scientific Archeology Unit

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

Original language	English
Pages (from-to)	2371-2377
Number of pages	7
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	11
DOIs	https://doi.org/10.1039/c4tb01959h
Publication status	Published - 2015

Funding

Publisher Copyright: © The Royal Society of Chemistry 2015.

All Science Journal Classification (ASJC) codes

General Chemistry
Biomedical Engineering
General Materials Science

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title = "Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging",

abstract = "Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.",

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language = "English",

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T1 - Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

AU - Tahir, Muhammad Nawaz

AU - Ragg, Ruben

AU - Natalio, Filipe

AU - Sahoo, Jugal Kishore

AU - Daniel, Phillip

AU - Koynov, Kaloian

AU - Strand, Dennis

AU - Strand, Susanne

AU - Tremel, Wolfgang

PY - 2015

Y1 - 2015

N2 - Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

AB - Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality. They are highly photostable, biocompatible and amenable to coupling with bioligands (e.g. secondary goat anti-rabbit antibody (GAR) and tri-phenyl phosphine (TPP)) via carbodiimide chemistry. Antibody (GAR) functionalized ZrO2 nanoparticles were used to image the nuclear protein Sirt6, whereas triphenyl phosphonium ion (TPP) functionalized ZrO2 nanoparticles specifically targeted the mitochondria. The versatility and easiness of the ZrO2 surface modification opens up new possibilities for designing non-toxic water dispersible and photostable photoluminescent NPs.

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DO - 10.1039/c4tb01959h

M3 - Article

SN - 2050-750X

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JF - Journal of Materials Chemistry B

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ER -

Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Abstract

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