ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Shoval Miyara; Eldad Tzahor

doi:10.1038/s44161-025-00621-5

ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Shoval Miyara, Eldad Tzahor^*

^*Corresponding author for this work

Department of Molecular Cell Biology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

Original language	English
Pages (from-to)	508-510
Number of pages	3
Journal	Nature Cardiovascular Research
Volume	4
Issue number	5
DOIs	https://doi.org/10.1038/s44161-025-00621-5
Publication status	Published - 29 Apr 2025

Funding

E.T.’s lab has been supported by the European Research Council, REANIMA European Union Framework Programme under “Horizon 2020”, and by the Israel Science Foundation.

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Cell Biology
Medicine (miscellaneous)
Cardiology and Cardiovascular Medicine

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10.1038/s44161-025-00621-5

Cite this

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title = "ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging",

abstract = "A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.",

author = "Shoval Miyara and Eldad Tzahor",

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T1 - ARID5A promotes inflammation and fibrosis during cardiac aging

T2 - Cardiac aging

AU - Miyara, Shoval

AU - Tzahor, Eldad

PY - 2025/4/29

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N2 - A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

AB - A systematic biology approach identifies an RNA-binding protein, ARID5A, as a regulator of inflammation and fibrosis in the aging human heart. Inhibition of ARID5A reduced inflammation and fibrosis and improved cardiac function in old mice.

UR - https://www.scopus.com/pages/publications/105004192262

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DO - 10.1038/s44161-025-00621-5

M3 - Comment/debate

AN - SCOPUS:105004192262

SN - 2731-0590

VL - 4

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JO - Nature Cardiovascular Research

JF - Nature Cardiovascular Research

IS - 5

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ARID5A promotes inflammation and fibrosis during cardiac aging: Cardiac aging

Abstract

Funding

All Science Journal Classification (ASJC) codes

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