Aspartic acid racemization and aging in cartilaginous tissue

Sarit Sara Sivan*, Alice Maroudas, Ellen Wachtel

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Depending on the composition of the extracellular matrix, cartilage in the human body is classified as elastic, fibrous, fibroelastic or hyaline. In this chapter, we will review what has been documented concerning AAR in two of these forms of cartilage: in fibroelastic cartilage, as exemplified by the IVD, and in articular cartilage, a specialized type of hyaline cartilage which provides a gliding surface for synovial joints. Both IVD and articular cartilage are aneural, avascular and alymphatic tissues, containing very few cells embedded in an extracellular matrix composed of diverse proteins which are described below.

Original languageEnglish
Title of host publicationMechanisms Linking Aging, Diseases and Biological Age Estimation
PublisherCRC Press
Chapter3
Pages21-35
Number of pages15
ISBN (Electronic)9781498709705
ISBN (Print)9781498709699
DOIs
Publication statusPublished - 22 Mar 2017

Funding

The authors wish to thank Dr. Peter Roughley (Shriners Hospital for Children, Montreal, Canada) for his critical reading of the manuscript and most helpful suggestions. Publisher Copyright: © 2017 by Taylor & Francis Group, LLC.

All Science Journal Classification (ASJC) codes

  • General Social Sciences
  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology

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