Abstract
Under atmospheric hydrogen pressure, a catalytic amount of palladium(II) trifluoroacetate and (R)-MeO-BIPHEP in 2,2,2-trifluoroethanol promoted the asymmetric hydrogenation of diisopropyl α-keto phosphonates 1 to afford the corresponding α-hydroxy phosphonates 2 in excellent yields and with a moderate enantioselectivities of up to 55 % ee. Racemic α-aryl-α- hydroxy phosphonates can be prepared by using palladium on carbon as the catalyst.
Original language | English |
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Pages (from-to) | 510-515 |
Number of pages | 6 |
Journal | European Journal of Organic Chemistry |
Issue number | 4 |
DOIs | |
Publication status | Published - Feb 2009 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry