ATI1 (ATG8-interacting protein 1) and ATI2 define a plant starvation-induced reticulophagy pathway and serve as MSBP1/MAPR5 cargo receptors

Jian Wu; Simon Michaeli; Lorenzo Picchianti; Yasin Dagdas; Gad Galili; Hadas Peled-zehavi

doi:10.1080/15548627.2021.1872886

ATI1 (ATG8-interacting protein 1) and ATI2 define a plant starvation-induced reticulophagy pathway and serve as MSBP1/MAPR5 cargo receptors

Jian Wu, Simon Michaeli, Lorenzo Picchianti, Yasin Dagdas, Gad Galili, Hadas Peled-zehavi

Department of Plant and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Reticulophagy, the selective autophagy of endoplasmic reticulum (ER) components, is known to operate in eukaryotes from yeast and unicellular algae to animals and plants. Thus far, only ER-stress induced reticulophagy was reported and analyzed in plants. In this study we characterize a reticulophagy pathway in Arabidopsis thaliana that is triggered by dark-induced starvation but not by ER stress. This pathway is defined by the previously reported ATG8-interacting proteins, ATI1 and ATI2. We further identified the ER-localized MSBP1 (Membrane Steroid Binding Protein 1) as an ATI1- and ATI2-interacting protein and an autophagy cargo, and show that ATI1 and ATI2 serve as its cargo receptors. Together, these findings expand our knowledge on plant responses during energy deprivation and highlight the role of this special type of reticulophagy in this process.

Original language	English
Pages (from-to)	1-14
Number of pages	14
Journal	Autophagy
Volume	17
Issue number	11
DOIs	https://doi.org/10.1080/15548627.2021.1872886
Publication status	Published Online - 25 Jan 2021

Funding

We thank Dr. Tamar Avin-Wittenberg for helpful scientific discussions. This work was supported by Israel Science Foundation (grant 612/16) and by an Israel’s Council for Higher Education Planning and Budgeting Committee (VATAT) postdoctoral fellowship to J.W. G.G. is the incumbent of the Bronfman Chair of Plant Sciences at The Weizmann Institute of Science.

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1080/15548627.2021.1872886

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title = "ATI1 (ATG8-interacting protein 1) and ATI2 define a plant starvation-induced reticulophagy pathway and serve as MSBP1/MAPR5 cargo receptors",

abstract = "Reticulophagy, the selective autophagy of endoplasmic reticulum (ER) components, is known to operate in eukaryotes from yeast and unicellular algae to animals and plants. Thus far, only ER-stress induced reticulophagy was reported and analyzed in plants. In this study we characterize a reticulophagy pathway in Arabidopsis thaliana that is triggered by dark-induced starvation but not by ER stress. This pathway is defined by the previously reported ATG8-interacting proteins, ATI1 and ATI2. We further identified the ER-localized MSBP1 (Membrane Steroid Binding Protein 1) as an ATI1- and ATI2-interacting protein and an autophagy cargo, and show that ATI1 and ATI2 serve as its cargo receptors. Together, these findings expand our knowledge on plant responses during energy deprivation and highlight the role of this special type of reticulophagy in this process.",

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AU - Michaeli, Simon

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AU - Dagdas, Yasin

AU - Galili, Gad

AU - Peled-zehavi, Hadas

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ATI1 (ATG8-interacting protein 1) and ATI2 define a plant starvation-induced reticulophagy pathway and serve as MSBP1/MAPR5 cargo receptors

Abstract

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