Biological implications of clonal hematopoiesis

Tiago C. Luis, Adam C. Wilkinson, Isabel Beerman*, Siddhartha Jaiswal, Liran Shlush

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Adult hematological malignancies, such as acute myeloid leukemia, are thought to arise through the gradual acquisition of oncogenic mutations within long-lived hematopoietic stem cells (HSCs). Genomic analysis of peripheral blood DNA has recently identified leukemia -associated genetic mutations within otherwise healthy individuals, an observation that is strongly associated with age. These genetic mutations are often found at high frequency, suggesting dominance of a mutant HSC clone. Expansion of clones carrying other mutations not associated with leukemia or larger chromosomal deletions was also observed. This clinical observation has been termed clonal hematopoiesis, a condition associated with increased risk of both hematological malignancy and cardiovascular disease. Here, we discuss the identification of clonal hematopoiesis and its implications on human health, based on the May 2019 International Society for Experimental Hematology New Investigator Committee Webinar. Published by Elsevier Inc. on behalf of ISEH - Society for Hematology and Stem Cells.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalExperimental Hematology
Volume77
DOIs
Publication statusPublished - Sept 2019

Funding

We thank the International Society for Experimental Hematology (ISEH) New Investigator Committee and the ISEH staff for their support. TCL is supported by a Sir Henry Dale Fellowship from the Wellcome Trust and The Royal Society, United Kingdom. ACW is a Special Fellow of The Leukemia & Lymphoma Society. IB is supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. SJ is supported by the Burroughs Wellcome Foundation, Evans Foundation, Ludwig Center, and Leducq Foundation.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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