Brain substrates of recovery from misleading influence

Micah G. Edelson, Yadin Dudai, Raymond J. Dolan, Tali Sharot

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Humans are strongly influenced by their environment, a dependence that can lead to errors in judgment. Although a rich literature describes how people are influenced by others, little is known regarding the factors that predict subsequent rectification of misleading influence. Using a mediation model in combination with brain imaging, we propose a model for the correction of misinformation. Specifically, our data suggest that amygdala modulation of hippocampal mnemonic representations, during the time of misleading social influence, is associated with reduced subsequent anterior-lateral prefrontal cortex activity that reflects correction. These findings illuminate the process by which erroneous beliefs are, or fail to be, rectified and highlight how past influence constrains subsequent correction.

Original languageEnglish
Pages (from-to)7744-7753
Number of pages10
JournalJournal of Neuroscience
Volume34
Issue number23
DOIs
Publication statusPublished - 2014

Funding

Weizmann Institute-United Kingdom Making Connections Grant; Wellcome Trust [098362/Z/12/Z, 091593/Z/10/Z]; Center of Research Excellence in the Cognitive Sciences of the Planning and Grants Committee; Israeli Science Foundation [51/11]; EP7 Human Brain Project; Norman and Helen Asher Center for Brain Imaging at the Weizmann Institute; Imaging Neuroscience & Theoretical Neurobiology group at the Wellcome Trust Center for Neuroimaging at University College LondonM.G.E. and Y.D. were supported by a Weizmann Institute-United Kingdom Making Connections Grant. T.S. was supported by a Wellcome Trust Career Development Fellowship. R.J.D. was supported by Wellcome Trust Senior Investigator Award 098362/Z/12/Z and a Wellcome Trust Strategic Award 091593/Z/10/Z. Y.D. was supported by the Center of Research Excellence in the Cognitive Sciences of the Planning and Grants Committee and Israeli Science Foundation (Grant 51/11) and by the EP7 Human Brain Project. We thank E. Phelps, J.G. Edelson, A. Ben-Yakov, L. Pell, K. Ludmer, T. Fitzgerald, S. Fleming, A. Mendelsohn, A. Pine, D. Kumaran, and N. Wright for helpful comments and the support teams of the Norman and Helen Asher Center for Brain Imaging at the Weizmann Institute and the Imaging Neuroscience & Theoretical Neurobiology group at the Wellcome Trust Center for Neuroimaging at University College London.

All Science Journal Classification (ASJC) codes

  • General Neuroscience

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