Abstract
Thio- and halodifluoromethylated compounds are an important class of compounds in medicinal chemistry and organic synthesis. Herein, we report a facile method for the construction of these compounds via chalcogenide-catalyzed intermolecular electrophilic thio- and halofunctionalization of gem-difluoroalkenes. Simple treatment of gem-difluoroalkenes with electrophilic sulfur/halogen reagents and various O- or N-nucleophiles affords diverse multifunctionalized thio- and halodifluoromethylated compounds. This reaction features a relatively broad substrate scope, good functional group tolerance, and mild reaction conditions.
Original language | English |
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Pages (from-to) | 7581-7587 |
Number of pages | 7 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2 Oct 2020 |
Externally published | Yes |
Funding
Publisher Copyright: © 2020 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry