Abstract
DNA chips are novel experimental tools that have revolutionized research in molecular biology and generated considerable excitement. A single chip allows simultaneous measurement of the level at which thousands of genes are expressed. A typical experiment uses a few tens of such chips, each focusing on one sample such as material extracted from a particular tumor. Hence the results of such an experiment contain several hundred thousand numbers, that come in the form of a table, of several thousand rows (one for each gene) and 50 - 100 columns (one for each sample). We developed a clustering methodology to mine such data. I provide here a very basic introduction to the subject, with no prior knowledge of any biology assumed. I will explain what genes are, what is gene expression and how it is measured by DNA chips. I will also explain what is meant by "clustering" and how we analyze the massive amounts of data from such experiments. I will present results obtained from analysis of data obtained from brain tumors and breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 175-195 |
| Number of pages | 21 |
| Journal | Modelling Biomedical Signals |
| DOIs | |
| Publication status | Published - 2002 |
| Event | International Workshop on Modelling Bio-Medical Signals - Bari, ITALY Duration: 19 Sept 2001 → 21 Sept 2001 |