TY - JOUR
T1 - Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test
AU - Makarov, Mark
AU - Sysoev, Yuri I.
AU - Agafonova, Oksana
AU - Prikhodko, Veronika A.
AU - Korkotian, Eduard
AU - Okovityi, Sergey V.
N1 - The work was performed using the equipment of the Analytical Center of the Russian Ministry of Health under Agreement no. 075152021685 of 26 July 2021, funded by the Russian Ministry of Education and Science. This work was performed within project ID: 93022798 of the St. Petersburg State University, St. Petersburg, Russia (for Y.I.S.).
PY - 2023/3
Y1 - 2023/3
N2 - One of the most important tasks in neuroscience is the search for theoretical foundations for the development of methods for diagnosing and treating neurological pathology, and for assessing the effect of pharmacological drugs on the nervous system. Specific behavioral changes associated with exposure to systemic influences have been invisible to the human eye for a long time. A similar pattern of changes is characteristic of phenazepam, a drug with a wide range of effects on the brain. In this study, we used a color-coding method, which consists of combining three time positions in one image, the present (0 s), the near future (0.33 s) and the far future (1.6 s). This method made it possible to identify movement patterns, such as the initialization of ahead movements, side turns and 180 degrees turns (back), and also to determine the degree of predictability of future movements. The obtained data revealed a decrease in the number of turns to the sides while maintaining ahead movement, as well as an increase in the predictability of movements in rats under the influence of phenazepam. Thus, sedative doses of phenazepam do not exhibit general depression of brain functions, but the inhibition of specific centers, including the medial prefrontal cortex and postsubiculum, which are involved in stereotypic locomotive behavior.
AB - One of the most important tasks in neuroscience is the search for theoretical foundations for the development of methods for diagnosing and treating neurological pathology, and for assessing the effect of pharmacological drugs on the nervous system. Specific behavioral changes associated with exposure to systemic influences have been invisible to the human eye for a long time. A similar pattern of changes is characteristic of phenazepam, a drug with a wide range of effects on the brain. In this study, we used a color-coding method, which consists of combining three time positions in one image, the present (0 s), the near future (0.33 s) and the far future (1.6 s). This method made it possible to identify movement patterns, such as the initialization of ahead movements, side turns and 180 degrees turns (back), and also to determine the degree of predictability of future movements. The obtained data revealed a decrease in the number of turns to the sides while maintaining ahead movement, as well as an increase in the predictability of movements in rats under the influence of phenazepam. Thus, sedative doses of phenazepam do not exhibit general depression of brain functions, but the inhibition of specific centers, including the medial prefrontal cortex and postsubiculum, which are involved in stereotypic locomotive behavior.
U2 - 10.3390/brainsci13030408
DO - 10.3390/brainsci13030408
M3 - Article
C2 - 36979218
SN - 2076-3425
VL - 13
JO - Brain Sciences
JF - Brain Sciences
IS - 3
M1 - 408
ER -