Comparison of Haloperidol- Versus Phenazepam- Induced Anxiolytic Effect on Rodent Behavior

This study investigated the effects of phenazepam and haloperidol, recognized as a tranquilizer and an antipsychotic, respectively, on anxiety using the open field test. We employed conventional behavioral assessments alongside color-tracing and color-coding methodologies to examine the comparative influences of two chosen drugs. Both compounds induced a reduction in locomotor activity, though with nuanced differences. Phenazepam’s suppressive effect manifested later, countered by increased traverses along the periphery, while haloperidol’s impact was evident earlier, accompanied by localized movements. Analysis of movement initiation revealed distinct patterns between the groups, suggesting phenazepam’s influence on cortical processes and haloperidol’s Impact on anxiety-related behavior. Despite reduced central exploration, interpretation of anxiety levels necessitates consideration of drug effects and environmental context. Our findings underscore the complexity of assessing anxiety solely based on motor activity, emphasizing the importance of incorporating emotional dimensions in clinical evaluations. This nuanced understanding is vital for optimizing therapeutic interventions in psychiatric care.