Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

Martin G. Low; Michael A.J. Ferguson; Anthony H. Futerman; Israel Silman

doi:10.1016/0968-0004(86)90009-5

Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

Martin G. Low^*, Michael A.J. Ferguson, Anthony H. Futerman, Israel Silman

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

178 Citations (Scopus)

Abstract

Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.

Original language	English
Pages (from-to)	212-215
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/0968-0004(86)90009-5
Publication status	Published - May 1986

All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry

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10.1016/0968-0004(86)90009-5

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title = "Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins",

abstract = "Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.",

author = "Low, {Martin G.} and Ferguson, {Michael A.J.} and Futerman, {Anthony H.} and Israel Silman",

year = "1986",

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T1 - Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

AU - Low, Martin G.

AU - Ferguson, Michael A.J.

AU - Futerman, Anthony H.

AU - Silman, Israel

PY - 1986/5

Y1 - 1986/5

N2 - Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.

AB - Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.

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U2 - 10.1016/0968-0004(86)90009-5

DO - 10.1016/0968-0004(86)90009-5

M3 - Review article

SN - 0968-0004

VL - 11

SP - 212

EP - 215

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 5

ER -

Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

Abstract

All Science Journal Classification (ASJC) codes

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