CRISPR–Cas: Spacer Diversity Determines the Efficiency of Defense

Anna Lopatina; Rotem Sorek

doi:10.1016/j.cub.2016.05.034

CRISPR–Cas: Spacer Diversity Determines the Efficiency of Defense

Anna Lopatina, Rotem Sorek^*

^*Corresponding author for this work

Department of Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

1 Citation (Scopus)

Abstract

Bacterial CRISPR–Cas systems acquire short sequences, called spacers, from viruses and plasmids, leading to adaptive immunity. The diversity of spacers within natural bacterial populations is very high. New data now explain how spacer diversity strengthens resistance of the bacterial population to phage infection.

Original language	English
Pages (from-to)	R683-R685
Journal	Current Biology
Volume	26
Issue number	14
DOIs	https://doi.org/10.1016/j.cub.2016.05.034
Publication status	Published - 25 Jul 2016

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences

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title = "CRISPR–Cas: Spacer Diversity Determines the Efficiency of Defense",

abstract = "Bacterial CRISPR–Cas systems acquire short sequences, called spacers, from viruses and plasmids, leading to adaptive immunity. The diversity of spacers within natural bacterial populations is very high. New data now explain how spacer diversity strengthens resistance of the bacterial population to phage infection.",

author = "Anna Lopatina and Rotem Sorek",

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year = "2016",

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doi = "10.1016/j.cub.2016.05.034",

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T1 - CRISPR–Cas

T2 - Spacer Diversity Determines the Efficiency of Defense

AU - Lopatina, Anna

AU - Sorek, Rotem

N1 - NA

PY - 2016/7/25

Y1 - 2016/7/25

N2 - Bacterial CRISPR–Cas systems acquire short sequences, called spacers, from viruses and plasmids, leading to adaptive immunity. The diversity of spacers within natural bacterial populations is very high. New data now explain how spacer diversity strengthens resistance of the bacterial population to phage infection.

AB - Bacterial CRISPR–Cas systems acquire short sequences, called spacers, from viruses and plasmids, leading to adaptive immunity. The diversity of spacers within natural bacterial populations is very high. New data now explain how spacer diversity strengthens resistance of the bacterial population to phage infection.

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U2 - 10.1016/j.cub.2016.05.034

DO - 10.1016/j.cub.2016.05.034

M3 - Short survey

SN - 0960-9822

VL - 26

SP - R683-R685

JO - Current Biology

JF - Current Biology

IS - 14

ER -

CRISPR–Cas: Spacer Diversity Determines the Efficiency of Defense

Abstract

All Science Journal Classification (ASJC) codes

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