De novo Design of Chemical Reaction Networks and Oscillators and Their Relation to Emergent Properties

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Abstract

Chemical reaction networks (CRNs) – cascades of chemical reactions where products of one reaction influence the rate of another reaction – are important in many fields of natural sciences. CRNs orchestrate cellular metabolism and guide the growth and movement of cells and multicellular organisms in heterogeneous environments. The chapter emphasizes two important conclusions from phenomenological nonequilibrium thermodynamics for the design of CRNs: quantitative requirements for the free energy of reactions and the importance of using open chemical systems. It considers two fundamental laws governing CRNs: mass conservation that results in stoichiometric restrictions and mass action. The stoichiometry significantly restricts the number of ways that concentrations of compounds can change during reactions. Continuously stirred tank reactor is the most common type of flow reactor employed in experimental studies. The current synthetic CRNs, the networks that are supposed to regulate artificial cells and smart therapeutic agents, are incomparable in their complexity to cellular regulatory networks.
Original languageEnglish
Title of host publicationOut‐of‐Equilibrium (Supra)molecular Systems and Materials
PublisherJohn Wiley and Sons
Pages91-130
Number of pages40
ISBN (Electronic)9783527821990
ISBN (Print)9783527346158
DOIs
Publication statusPublished - 19 Apr 2021

Funding

Publisher Copyright: © 2021 WILEY-VCH GmbH, Boschstr. 12, 69469 Weinheim, Germany.

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