Defining myeloid-derived suppressor cells

Leila Akkari; Ido Amit; Vincenzo Bronte; Zvi G. Fridlender; Dmitry I. Gabrilovich; Florent Ginhoux; Catherine C. Hedrick; Suzanne Ostrand-Rosenberg

doi:10.1038/s41577-024-01062-0

Defining myeloid-derived suppressor cells

Leila Akkari^*, Ido Amit^*, Vincenzo Bronte^*, Zvi G. Fridlender^*, Dmitry I. Gabrilovich^*, Florent Ginhoux^*, Catherine C. Hedrick^*, Suzanne Ostrand-Rosenberg^*

^*Corresponding author for this work

Department of Systems Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

Original language	English
Number of pages	8
Journal	Nature Reviews Immunology
DOIs	https://doi.org/10.1038/s41577-024-01062-0
Publication status	Published Online - 5 Jul 2024

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Publisher Copyright:
© Springer Nature Limited 2024.

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1038/s41577-024-01062-0

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title = "Defining myeloid-derived suppressor cells",

abstract = "Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.",

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AU - Amit, Ido

AU - Bronte, Vincenzo

AU - Fridlender, Zvi G.

AU - Gabrilovich, Dmitry I.

AU - Ginhoux, Florent

AU - Hedrick, Catherine C.

AU - Ostrand-Rosenberg, Suzanne

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N2 - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

AB - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

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JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

ER -

Defining myeloid-derived suppressor cells

Abstract

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