Abstract
Summary Zebrafish is a small and hardy tropical cyprinid. Zebrafish has around 26K protein-coding genes, of which around 70% have orthologs in humans. Neuroendocrine regulation of physiology and homeostasis in zebrafish requires orchestrated activation of the hypothalamus and pituitary gland as well as various peripheral organs including the interrenal gland, gonads, fat, digestive system, liver, pancreas, kidney and gills. This chapter describes the anatomy and development of the interrenal gland and gonads, which are cardinal for the regulation of stress and reproduction. Cell type specification during hypothalamic development is regulated by intrinsic transcription factors (TFs) and extrinsic secreted factors and neuropeptides. The pituitary gland of fish and mammals serves as an interface linking between the hypothalamic neuroendocrine neurons and the peripheral body. The hypothalamo-neurohypophyseal system (HNS) is composed of hypothalamic magnocellular neurons which produce Oxt and Avp, with axonal projections that innervate the neurohypophysis, which serves as the release site for these neuropeptides.
| Original language | English |
|---|---|
| Title of host publication | Model Animals in Neuroendocrinology |
| Publisher | Wiley Blackwell |
| Pages | 101-131 |
| Number of pages | 31 |
| ISBN (Print) | 9781119391128 |
| DOIs | |
| Publication status | Published - 2018 |