Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

Lucas Nogueira; Andrew T. Tracey; Ricardo Alvim; Peter Reisz; Avigdor Scherz; Jonathan A. Coleman; Kwanghee Kim

doi:10.3390/molecules25225417

Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

Lucas Nogueira, Andrew T. Tracey, Ricardo Alvim, Peter Reisz, Avigdor Scherz, Jonathan A. Coleman, Kwanghee Kim

Department of Plant and Environmental Sciences

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.

Original language	English
Article number	5417
Number of pages	12
Journal	Molecules (Basel, Switzerland)
Volume	25
Issue number	22
DOIs	https://doi.org/10.3390/molecules25225417
Publication status	Published - Nov 2020

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies",

abstract = "With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.",

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T1 - Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

AU - Nogueira, Lucas

AU - Tracey, Andrew T.

AU - Alvim, Ricardo

AU - Reisz, Peter

AU - Scherz, Avigdor

AU - Coleman, Jonathan A.

AU - Kim, Kwanghee

PY - 2020/11

Y1 - 2020/11

N2 - With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.

AB - With improved understanding of cancer biology and technical advancements in non-invasive management of urological malignancies, there is renewed interest in photodynamic therapy (PDT) as a means of focal cancer treatment. The application of PDT has also broadened as a result of development of better-tolerated and more effective photosensitizers. Vascular-targeted PDT (VTP) using padeliporfin, which is a water-soluble chlorophyll derivative, allows for tumor-specific cytotoxicity and has demonstrated efficacy in the management of urologic malignancies. Herein, we describe the evolution of photodynamic therapy in urologic oncology and the role of VTP in emerging treatment paradigms.

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DO - 10.3390/molecules25225417

M3 - Review article

C2 - 33228126

AN - SCOPUS:85096736816

SN - 1420-3049

VL - 25

JO - Molecules (Basel, Switzerland)

JF - Molecules (Basel, Switzerland)

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M1 - 5417

ER -

Developments in Vascular-Targeted Photodynamic Therapy for Urologic Malignancies

Abstract

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