TY - JOUR
T1 - Diffusion-Tensor MR Imaging of the Breast
T2 - Hormonal Regulation
AU - Nissan, Noam
AU - Furman-Haran, Edna
AU - Shapiro-Feinberg, Myra
AU - Grobgeld, Dov
AU - Degani, Hadassa
PY - 2014/6
Y1 - 2014/6
N2 - Purpose: To investigate the parameters obtained with magnetic resonance (MR) diffusion-tensor imaging (DTI) of the breast throughout the menstrual cycle phases, during lactation, and after menopause, with and without hormone replacement therapy (HRT). Materials and Methods: All protocols were approved by the internal review board, and signed informed consent was obtained from all participants. Forty-five healthy volunteers underwent imaging by using T2-weighted and DTI MR sequences at 3 T. Premenopausal volunteers (n = 16) underwent imaging weekly, four times during one menstrual cycle. Postmenopausal volunteers (n = 19) and lactating volunteers (n = 10) underwent imaging once. The principal diffusion coefficients (lambda 1, lambda 2, and lambda 3), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and maximal anisotropy (lambda 1-lambda 3) were calculated pixel by pixel for the fibroglandular tissue in the entire breast. Results: In all premenopausal volunteers, the DTI parameters exhibited high repeatability, remaining almost equal along the menstrual cycle, with a low mean within-subject coefficient of variance of lambda 1, lambda 2, lambda 3, and ADC (1%-2% for all) and FA (5%), as well as a high intraclass correlation of 0.92-0.98. The diffusion coefficients were significantly lower (a) in the group without HRT use as compared with the group with HRT use (P <.01) and premenopausal volunteers (P <.01) and (b) in the lactating volunteers as compared with the premenopausal volunteers (P <.005). No significant differences in DTI parameters were found between premenopausal volunteers free of oral contraceptives and those who used oral contraceptives (P = .28-0.82) and between premenopausal volunteers and postmenopausal volunteers who used HRT (P = .31-0.93). Conclusion: DTI parameters are not sensitive to menstrual cycle changes, while menopause, long-term HRT, and presence of milk in lactating women affected the DTI parameters. Therefore, the
AB - Purpose: To investigate the parameters obtained with magnetic resonance (MR) diffusion-tensor imaging (DTI) of the breast throughout the menstrual cycle phases, during lactation, and after menopause, with and without hormone replacement therapy (HRT). Materials and Methods: All protocols were approved by the internal review board, and signed informed consent was obtained from all participants. Forty-five healthy volunteers underwent imaging by using T2-weighted and DTI MR sequences at 3 T. Premenopausal volunteers (n = 16) underwent imaging weekly, four times during one menstrual cycle. Postmenopausal volunteers (n = 19) and lactating volunteers (n = 10) underwent imaging once. The principal diffusion coefficients (lambda 1, lambda 2, and lambda 3), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and maximal anisotropy (lambda 1-lambda 3) were calculated pixel by pixel for the fibroglandular tissue in the entire breast. Results: In all premenopausal volunteers, the DTI parameters exhibited high repeatability, remaining almost equal along the menstrual cycle, with a low mean within-subject coefficient of variance of lambda 1, lambda 2, lambda 3, and ADC (1%-2% for all) and FA (5%), as well as a high intraclass correlation of 0.92-0.98. The diffusion coefficients were significantly lower (a) in the group without HRT use as compared with the group with HRT use (P <.01) and premenopausal volunteers (P <.01) and (b) in the lactating volunteers as compared with the premenopausal volunteers (P <.005). No significant differences in DTI parameters were found between premenopausal volunteers free of oral contraceptives and those who used oral contraceptives (P = .28-0.82) and between premenopausal volunteers and postmenopausal volunteers who used HRT (P = .31-0.93). Conclusion: DTI parameters are not sensitive to menstrual cycle changes, while menopause, long-term HRT, and presence of milk in lactating women affected the DTI parameters. Therefore, the
U2 - 10.1148/radiol.14132084
DO - 10.1148/radiol.14132084
M3 - Article
SN - 0033-8419
VL - 271
SP - 672
EP - 680
JO - Radiology
JF - Radiology
IS - 3
ER -