Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Michal Ramot; Catherine Walsh; Gabrielle Elise Reimann; Alex Martin

doi:10.1038/s42003-020-0771-1

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Michal Ramot^*, Catherine Walsh, Gabrielle Elise Reimann, Alex Martin

^*Corresponding author for this work

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Extensive study of typically developing individuals and those on the autism spectrum has identified a large number of brain regions associated with our ability to navigate the social world. Although it is widely appreciated that this so-called “social brain” is composed of distinct, interacting systems, these component parts have yet to be clearly elucidated. Here we used measures of eye movement and neural typicality—based on the degree to which subjects deviated from the norm—while typically developing (N = 62) and individuals with autism (N = 36) watched a large battery of movies depicting social interactions. Our findings provide clear evidence for distinct, but overlapping, neural systems underpinning two major components of the “social brain,” social orienting, and inferring the mental state of others.

Original language	English
Article number	48
Number of pages	11
Journal	Communications Biology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/s42003-020-0771-1
Publication status	Published - 29 Jan 2020

Bibliographical note

We thank Adrian Gilmore, Andrew Persichetti, and Stephen Gotts for many helpful conversations and insights, and Kelsey Csumitta for help with recruitment. This work was supported by the Intramural Research Program, National Institute of Mental Health (ZIAMH002920), clinical trials number NCT01031407.
Contributions
M.R. and A.M. conceived and designed the study. M.R., C.W., and G.R. collected and analyzed the data. C.W. created the experimental stimuli. M.R. and A.M. wrote the paper and all authors commented on the paper.

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Agricultural and Biological Sciences
Medicine (miscellaneous)

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10.1038/s42003-020-0771-1Licence: CC BY

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title = "Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality",

abstract = "Extensive study of typically developing individuals and those on the autism spectrum has identified a large number of brain regions associated with our ability to navigate the social world. Although it is widely appreciated that this so-called “social brain” is composed of distinct, interacting systems, these component parts have yet to be clearly elucidated. Here we used measures of eye movement and neural typicality—based on the degree to which subjects deviated from the norm—while typically developing (N = 62) and individuals with autism (N = 36) watched a large battery of movies depicting social interactions. Our findings provide clear evidence for distinct, but overlapping, neural systems underpinning two major components of the “social brain,” social orienting, and inferring the mental state of others.",

author = "Michal Ramot and Catherine Walsh and Reimann, {Gabrielle Elise} and Alex Martin",

note = "We thank Adrian Gilmore, Andrew Persichetti, and Stephen Gotts for many helpful conversations and insights, and Kelsey Csumitta for help with recruitment. This work was supported by the Intramural Research Program, National Institute of Mental Health (ZIAMH002920), clinical trials number NCT01031407. Contributions M.R. and A.M. conceived and designed the study. M.R., C.W., and G.R. collected and analyzed the data. C.W. created the experimental stimuli. M.R. and A.M. wrote the paper and all authors commented on the paper.",

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Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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