Donor cell leukemia: reappearance of gene mutations in donor cells - more than an incidental phenomenon?

Tal Shahar Gabay, Noa Chapal-Ilani, Yoni Moskovitz, Tamir Biezuner, Barak Oron, Yardena Brilon, Anna Fridman-Dror, Rawan Sabah, Ran Balicer, Amos Tanay, Netta Mendelson-Cohen, Eldad J Dann, Riva Fineman, Nathali Kaushansky, Shlomit Yehudai-Reshef, Tsila Zuckerman, Liran I Shlush

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Acute myeloid leukemia (AML) is one of the extreme outcomes of age-related clonal hematopoiesis (ARCH)1. With aging, mutations accumulate in hematopoietic stem and progenitor cells (HSPCs)2,3. Based on the estimated number of HSPCs (~50,000) in the human body and the number of somatic mutations in adult single cells (~1000)4, it is predicted that every ~100 nucleotides, a somatic mutation will occur at a low variant allele frequency (VAF).
Original languageEnglish
Pages (from-to)2861-2863
Number of pages3
JournalHaematologica
Volume105
Issue number12
Early online date7 May 2020
DOIs
Publication statusPublished - Dec 2020

Funding

This work was supported by the Israel Cancer Association, grants # 20170179 and 20181136. Author Contribution: T.S.-G. designed and performed research, wrote the paper, approved the final version of the paper N.C.-I. performed research, interpreted the data, approved the final version of the paper Y.M. performed research, approved the final version of the paper T.B. performed research, approved the final version of the paper B.A, performed research, approved the final version of the paper Y.B. performed research, approved the final version of the paper A.F.-D. performed research, approved the final version of the paper R.S. performed research, approved the final version of the paper R.B. performed research, approved the final version of the paper O. N. performed research, approved the final version of the paper A.T. performed research, approved the final version of the paper N.M-C. performed research, approved the final version of the paper E.J.D. collected the data, approved the final version of the paper R.V. collected the data, approved the final version of the paper N.K. designed research, interpreted the data, approved the final version of the paper S.Y.-R. designed research, interpreted the data, wrote the paper, approved the final version of the paper T.Z. designed research, interpreted the data, wrote the paper, approved the final version of the paper L.S. designed research, interpreted the data, wrote the paper, approved the final version of the paper

All Science Journal Classification (ASJC) codes

  • Hematology

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