Abstract
An efficient and convenient pathway was developed for enantioselective synthesis of chiral sulfides by chiral bifunctional selenide-catalyzed electrophilic azidothiolation and oxythiolation of N-allyl sulfonamides. By this protocol, a variety of chiral vicinal azidosulfides and oxysulfides were obtained in good yields with high enantioselectivities and diastereoselectivities. In this transformation, not only electrophilic arylthiolating reagents but also a wide range of electrophilic alkylthiolating reagents worked very well. The practical application of this method was elucidated by further transformations of the products into the diversified compounds.
Original language | English |
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Pages (from-to) | 6896-6902 |
Number of pages | 7 |
Journal | ACS Catalysis |
Volume | 9 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2 Aug 2019 |
Externally published | Yes |
Funding
Publisher Copyright: © 2019 American Chemical Society.
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry