Enhancement of consolidated long-term memory by overexpression of protein kinase Mζ in the neocortex

Reut Shema; Sharon Haramati; Shiri Ron; Shoshi Hazvi; Alon Chen; Todd Charlton Sacktor; Yadin Dudai

doi:10.1126/science.1200215

Enhancement of consolidated long-term memory by overexpression of protein kinase Mζ in the neocortex

Reut Shema, Sharon Haramati, Shiri Ron, Shoshi Hazvi, Alon Chen, Todd Charlton Sacktor, Yadin Dudai

Department of Brain Sciences

Research output: Contribution to journal › Article › peer-review

148 Citations (Scopus)

Abstract

Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.

Original language	English
Pages (from-to)	1207-1210
Number of pages	4
Journal	Science
Volume	331
Issue number	6021
DOIs	https://doi.org/10.1126/science.1200215
Publication status	Published - 4 Mar 2011

Funding

Israel-U.S. Binational Science Foundation; Nella and Leon Benoziyo Center for Neurologica Diseases; NIH [R01 MH53576, MH57068]; Israeli Academy of Sciences and HumanitiesThe support of the Israel-U.S. Binational Science Foundation (Y.D and T.C.S), the Nella and Leon Benoziyo Center for Neurologica Diseases (Y.D.), and of NIH R01 MH53576 and MH57068 (T.C.S.) is gratefully acknowledged. R.S. is supported by the Adams Fellowship program of the Israeli Academy of Sciences and Humanities. We thank R. Eilam for providing invaluable assistance in histochemistry.

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10.1126/science.1200215

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abstract = "Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.",

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AU - Hazvi, Shoshi

AU - Chen, Alon

AU - Sacktor, Todd Charlton

AU - Dudai, Yadin

PY - 2011/3/4

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AB - Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mz (PKMz) enhances long-term memory, whereas a dominant negative PKMz disrupts memory, even long after memory has been formed.

UR - https://www.scopus.com/pages/publications/79952264714

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Enhancement of consolidated long-term memory by overexpression of protein kinase Mζ in the neocortex

Abstract

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