TY - JOUR
T1 - Extracellular Vesicles
T2 - A Prevalent Tool for Microbial Gene Delivery?
AU - Ben-Hur, Sharon
AU - Biton, Mirit
AU - Regev-Rudzki, Neta
N1 - N.R.-R. is grateful for the support from the European Research Council(ERC) under the European Union’s Horizon 2020 research and innovationprogram (grant agreement No 757743), and the Israel Science Foundation(ISF) (619/16 and 119034).
PY - 2019/1
Y1 - 2019/1
N2 - Genetic plasticity of prokaryotic microbial communities is largely dependent on the ongoing exchange of genetic determinants by Horizontal Gene Transfer (HGT). HGT events allow beneficial genetic transitions to occur throughout microbial life, thus promoting adaptation to changing environmental conditions. Here, the significance of secreted vesicles in mediating HGT between microorganisms is discussed, while focusing on the benefits gained by vesicle-mediated gene delivery and its occurrence under different environmental cues. The potential use of secreted DNA-harboring vesicles as a mechanism of currently unresolved HGT events in eukaryotic microbes is further discussed.
AB - Genetic plasticity of prokaryotic microbial communities is largely dependent on the ongoing exchange of genetic determinants by Horizontal Gene Transfer (HGT). HGT events allow beneficial genetic transitions to occur throughout microbial life, thus promoting adaptation to changing environmental conditions. Here, the significance of secreted vesicles in mediating HGT between microorganisms is discussed, while focusing on the benefits gained by vesicle-mediated gene delivery and its occurrence under different environmental cues. The potential use of secreted DNA-harboring vesicles as a mechanism of currently unresolved HGT events in eukaryotic microbes is further discussed.
UR - http://www.scopus.com/inward/record.url?scp=85057855486&partnerID=8YFLogxK
U2 - 10.1002/pmic.201800170
DO - 10.1002/pmic.201800170
M3 - Article
SN - 1615-9853
VL - 19
JO - Proteomics
JF - Proteomics
IS - 1-2
M1 - 1800170
ER -