TY - CONF
T1 - Functional imaging of tumor vascular network in small animal models
AU - Kalchenko, Vyacheslav
AU - Madar-Balakirski, Noa
AU - Kuznetsov, Yuri
AU - Meglinski, Igor
AU - Harmelin, Alon
N1 - This work was supported in part by the Estate of Florence Blau and Lewis Family Trust (VK). Authors acknowledge the support of 2010-2011 PBRF Research Output Publishing Grant, University of Otago (New Zealand) and Weizmann Institute of Science (Israel) and partial support provided by Federal target program “Research and Pedagogical Cadre for Innovative Russia” for 2009-2013 (grant project: 02.740.11.5136).
PY - 2011/6/9
Y1 - 2011/6/9
N2 - In current report we present synchronized in vivo imaging of tumor vascular network and tumor microenvironment obtained by combined use of Dynamic Light Scattering Imaging, Spectrally Enhanced Microscopy, and Fluorescence Intravital Microscopy. Dynamic Light Scattering Imaging is used for functional imaging of the vascular network and blood microcirculation. Spectrally Enhanced Microscopy provides information regarding blood vessel topography. Fluorescence Intravital Microscopy is used for imaging of tumor microvasculature and tumor microenvironment. These well known modalities have been comprehensively validated in the past and are widely used in various bio-medical applications. As shown here, their combined application has great potential for studies of vascular biology. This multi-modal non-invasive diagnostic technique expands our current capacity to investigate blood microcirculation and tumor angiogenesis in vivo, thereby contributing to the development of cancer research and treatment.
AB - In current report we present synchronized in vivo imaging of tumor vascular network and tumor microenvironment obtained by combined use of Dynamic Light Scattering Imaging, Spectrally Enhanced Microscopy, and Fluorescence Intravital Microscopy. Dynamic Light Scattering Imaging is used for functional imaging of the vascular network and blood microcirculation. Spectrally Enhanced Microscopy provides information regarding blood vessel topography. Fluorescence Intravital Microscopy is used for imaging of tumor microvasculature and tumor microenvironment. These well known modalities have been comprehensively validated in the past and are widely used in various bio-medical applications. As shown here, their combined application has great potential for studies of vascular biology. This multi-modal non-invasive diagnostic technique expands our current capacity to investigate blood microcirculation and tumor angiogenesis in vivo, thereby contributing to the development of cancer research and treatment.
U2 - 10.1117/12.890746
DO - 10.1117/12.890746
M3 - Paper
T2 - Conference on Novel Biophotonic Techniques and Applications
Y2 - 22 May 2011 through 24 May 2011
ER -