GD3 ganglioside checkpoints in immune surveillance of senescent cells: Immune surveillance

Julia Majewska; Valery Krizhanovsky

doi:10.1038/s43587-025-00803-7

GD3 ganglioside checkpoints in immune surveillance of senescent cells: Immune surveillance

Julia Majewska, Valery Krizhanovsky^*

^*Corresponding author for this work

Department of Molecular Cell Biology

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.

Original language	English
Article number	5435
Pages (from-to)	182-183
Number of pages	2
Journal	Nature Aging
Volume	5
Issue number	2
DOIs	https://doi.org/10.1038/s43587-025-00803-7
Publication status	Published - Feb 2025

Funding

V.K. was supported by grants from the European Research Council (856487), from the Israel Science Foundation (1626/20), DFG - CRC 1506 “Aging at Interfaces”, Weizmann - Nella and Leon Benoziyo Center for Neurological Diseases, Weizmann - Sagol Center for Research on the Aging Brain, Weizmann SABRA - Yeda-Sela - WRC Program, the Estate of Emile Mimran, and The Maurice and Vivienne Wohl Biology Endowment.

All Science Journal Classification (ASJC) codes

Neuroscience (miscellaneous)
Ageing
Geriatrics and Gerontology

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abstract = "Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.",

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AB - Iltis, Moskalevska and colleagues investigate how the innate immune system regulates the age-related accumulation of senescent cells. They show that upregulation of the GD3 ganglioside-based immune checkpoint enables senescent cells to evade immune surveillance mediated by natural killer cells during aging, and that targeting GD3 is protective in age-related disease.

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GD3 ganglioside checkpoints in immune surveillance of senescent cells: Immune surveillance

Abstract

Funding

All Science Journal Classification (ASJC) codes

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