Genetic Redundancy: New Tricks for Old Genes

Ran Kafri; Michael Springer; Yitzhak Pilpel

doi:10.1016/j.cell.2009.01.027

Genetic Redundancy: New Tricks for Old Genes

Ran Kafri^*, Michael Springer, Yitzhak Pilpel

^*Corresponding author for this work

Department of Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

137 Citations (Scopus)

Abstract

Many crucial components of signal transduction, developmental, and metabolic pathways have functionally redundant copies. Further, these redundancies show surprising evolutionary stability over prolonged time scales. We propose that redundancies are not just archeological leftovers of ancient gene duplications, but rather that synergy arising from feedback between redundant copies may serve as an information processing element that facilitates signal transduction and the control of gene expression.

Original language	English
Pages (from-to)	389-392
Number of pages	4
Journal	Cell
Volume	136
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2009.01.027
Publication status	Published - 6 Feb 2009

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2009.01.027

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title = "Genetic Redundancy: New Tricks for Old Genes",

abstract = "Many crucial components of signal transduction, developmental, and metabolic pathways have functionally redundant copies. Further, these redundancies show surprising evolutionary stability over prolonged time scales. We propose that redundancies are not just archeological leftovers of ancient gene duplications, but rather that synergy arising from feedback between redundant copies may serve as an information processing element that facilitates signal transduction and the control of gene expression.",

author = "Ran Kafri and Michael Springer and Yitzhak Pilpel",

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AU - Kafri, Ran

AU - Springer, Michael

AU - Pilpel, Yitzhak

PY - 2009/2/6

Y1 - 2009/2/6

N2 - Many crucial components of signal transduction, developmental, and metabolic pathways have functionally redundant copies. Further, these redundancies show surprising evolutionary stability over prolonged time scales. We propose that redundancies are not just archeological leftovers of ancient gene duplications, but rather that synergy arising from feedback between redundant copies may serve as an information processing element that facilitates signal transduction and the control of gene expression.

AB - Many crucial components of signal transduction, developmental, and metabolic pathways have functionally redundant copies. Further, these redundancies show surprising evolutionary stability over prolonged time scales. We propose that redundancies are not just archeological leftovers of ancient gene duplications, but rather that synergy arising from feedback between redundant copies may serve as an information processing element that facilitates signal transduction and the control of gene expression.

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U2 - 10.1016/j.cell.2009.01.027

DO - 10.1016/j.cell.2009.01.027

M3 - Short survey

SN - 0092-8674

VL - 136

SP - 389

EP - 392

JO - Cell

JF - Cell

IS - 3

ER -

Genetic Redundancy: New Tricks for Old Genes

Abstract

All Science Journal Classification (ASJC) codes

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