HSF1 renders NK cells too stressed to respond

Yael Gruper; Aviad Ben-Shmuel; Ruth Scherz-Shouval

doi:10.1038/s41556-024-01472-1

HSF1 renders NK cells too stressed to respond

Yael Gruper, Aviad Ben-Shmuel, Ruth Scherz-Shouval^*

^*Corresponding author for this work

Department of Biomolecular Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.

Original language	English
Journal	Nature Cell Biology
DOIs	https://doi.org/10.1038/s41556-024-01472-1
Publication status	Published Online - 2 Sept 2024

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1038/s41556-024-01472-1

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title = "HSF1 renders NK cells too stressed to respond",

abstract = "The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.",

author = "Yael Gruper and Aviad Ben-Shmuel and Ruth Scherz-Shouval",

year = "2024",

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doi = "10.1038/s41556-024-01472-1",

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T1 - HSF1 renders NK cells too stressed to respond

AU - Gruper, Yael

AU - Ben-Shmuel, Aviad

AU - Scherz-Shouval, Ruth

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AB - The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.

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DO - 10.1038/s41556-024-01472-1

M3 - Comment/debate

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SN - 1465-7392

JO - Nature Cell Biology

JF - Nature Cell Biology

ER -

HSF1 renders NK cells too stressed to respond

Abstract

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