Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition

Mehmet Yunus Comar; Bernardo Oldak; Jacob H. Hanna

doi:10.1016/j.devcel.2025.04.007

Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition

Mehmet Yunus Comar, Bernardo Oldak, Jacob H. Hanna^*

^*Corresponding author for this work

Department of Molecular Genetics

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Understanding the functional regulatory landscape of maternal-to-zygotic transition (MZT) during early human embryo development remains a challenge. In this issue of Developmental Cell, Guo et al. assessed single-cell allele-specific transcriptomics from human preimplantation embryos and identified DPRX and ARGFX genes as pivotal factors whose hampered activation underlies cleavage-stage embryonic arrest.

Original language	English
Pages (from-to)	1277-1279
Number of pages	3
Journal	Developmental Cell
Volume	60
Issue number	9
DOIs	https://doi.org/10.1016/j.devcel.2025.04.007
Publication status	Published - 5 May 2025

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry,Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2025.04.007

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title = "Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition",

abstract = "Understanding the functional regulatory landscape of maternal-to-zygotic transition (MZT) during early human embryo development remains a challenge. In this issue of Developmental Cell, Guo et al. assessed single-cell allele-specific transcriptomics from human preimplantation embryos and identified DPRX and ARGFX genes as pivotal factors whose hampered activation underlies cleavage-stage embryonic arrest.",

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year = "2025",

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doi = "10.1016/j.devcel.2025.04.007",

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AU - Comar, Mehmet Yunus

AU - Oldak, Bernardo

AU - Hanna, Jacob H.

PY - 2025/5/5

Y1 - 2025/5/5

N2 - Understanding the functional regulatory landscape of maternal-to-zygotic transition (MZT) during early human embryo development remains a challenge. In this issue of Developmental Cell, Guo et al. assessed single-cell allele-specific transcriptomics from human preimplantation embryos and identified DPRX and ARGFX genes as pivotal factors whose hampered activation underlies cleavage-stage embryonic arrest.

AB - Understanding the functional regulatory landscape of maternal-to-zygotic transition (MZT) during early human embryo development remains a challenge. In this issue of Developmental Cell, Guo et al. assessed single-cell allele-specific transcriptomics from human preimplantation embryos and identified DPRX and ARGFX genes as pivotal factors whose hampered activation underlies cleavage-stage embryonic arrest.

UR - https://www.scopus.com/pages/publications/105003753028

U2 - 10.1016/j.devcel.2025.04.007

DO - 10.1016/j.devcel.2025.04.007

M3 - Comment/debate

AN - SCOPUS:105003753028

SN - 1534-5807

VL - 60

SP - 1277

EP - 1279

JO - Developmental Cell

JF - Developmental Cell

IS - 9

ER -

Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition

Abstract

All Science Journal Classification (ASJC) codes

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