Magnetic mixed micelles composed of a non-ionic surfactant and nitroxide radicals containing a D-glucosamine unit: Preparation, stability, and biomedical application

Kota Nagura, Yusa Takemoto, Fumi Yoshino, Alexey Bogdanov, Natalia Chumakova, Andrey Kh Vorobiev, Hirohiko Imai, Tetsuya Matsuda, Satoshi Shimono, Tatsuhisa Kato, Naoki Komatsu*, Rui Tamura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Metal-free magnetic mixed micelles (mean diameter: < 20 nm) were prepared by mixing the biocompatible non-ionic surfactant Tween 80 and the non-toxic, hydrophobic pyrrolidine-N-oxyl radicals bearing a D-glucosamine unit in pH 7.4 phosphate-buffered saline (PBS). The time-course stability and in vitro magnetic resonance imaging (MRI) contrast ability of the mixed micelles was found to depend on the length of the alkyl chain in the nitroxide radicals. It was also confirmed that the mixed micelles exhibited no toxicity in vivo and in vitro and high stability in the presence of a large excess of ascorbic acid. The in vivo MRI experiment revealed that one of these mixed micelles showed much higher contrast enhancement in the proton longitudinal relaxation time (T 1 ) weighted images than other magnetic mixed micelles that we have reported previously. Thus, the magnetic mixed micelles presented here are expected to serve as a promising contrast agent for theranostic nanomedicines, such as MRI-visible targeted drug delivery carriers.

Original languageEnglish
Article number42
JournalPharmaceutics
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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