Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

Tatyana L. Povolotsky; Alona Keren-Paz; Ilana Kolodkin-Gal

doi:10.1016/j.tig.2020.10.007

Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

Tatyana L. Povolotsky, Alona Keren-Paz, Ilana Kolodkin-Gal^*

^*Corresponding author for this work

Department of Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

21 Citations (Scopus)

Abstract

For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.

Original language	English
Pages (from-to)	4-8
Number of pages	5
Journal	Trends in Genetics
Issue number	1
DOIs	https://doi.org/10.1016/j.tig.2020.10.007
Publication status	Accepted/In press - 14 Nov 2020

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/j.tig.2020.10.007

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title = "Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance",

abstract = "For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.",

author = "Povolotsky, {Tatyana L.} and Alona Keren-Paz and Ilana Kolodkin-Gal",

year = "2020",

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T1 - Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

AU - Povolotsky, Tatyana L.

AU - Keren-Paz, Alona

AU - Kolodkin-Gal, Ilana

PY - 2020/11/14

Y1 - 2020/11/14

N2 - For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.

AB - For bacteria, the transition from unicellular entities to multicellular biofilm communities generates distinct metabolic microenvironments. Dynamic and programmed metabolic responses allow the biofilms to react to local changes in nutrient levels. Moreover, metabolic adaptations contribute to phenotypic antibiotic resistance of the community, suggesting novel therapeutic approaches to target biofilms.

U2 - 10.1016/j.tig.2020.10.007

DO - 10.1016/j.tig.2020.10.007

M3 - Short survey

AN - SCOPUS:85096167948

SN - 0168-9525

SP - 4

EP - 8

JO - Trends in Genetics

JF - Trends in Genetics

IS - 1

ER -

Metabolic Microenvironments Drive Microbial Differentiation and Antibiotic Resistance

Abstract

All Science Journal Classification (ASJC) codes

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