Abstract
Macrophages have emerged as critical cellular components of the central nervous system (CNS), promoting development, maintenance, and immune defense of the CNS. Here we will review recent advances in our understanding of brain macrophage heterogeneity, including microglia and border-associated macrophages, focusing on the mouse. Emphasis will be given to the discussion of strengths and limitations of the experimental approaches that have led to the recent insights and hold promise to further deepen our mechanistic understanding of brain macrophages that might eventually allow to harness their activities for the management of CNS pathologies.
| Original language | English |
|---|---|
| Pages (from-to) | 5-18 |
| Number of pages | 14 |
| Journal | GLIA |
| Volume | 72 |
| Issue number | 1 |
| Early online date | 28 Jul 2023 |
| DOIs | |
| Publication status | Published - Jan 2024 |
Funding
Funding Information: We thank members of the Jung laboratory for helpful discussions. This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project‐ID 259373024—TRR 167 and the Priority Programme “” (SPP 2395). Steffen Jung is the incumbent of the Henry HG. Drake Professional Chair of Immunology. This research was generously supported by Morris Kahn Institute for Human Immunology. Local and Peripheral Drivers of Microglial Diversity and Function Publisher Copyright: © 2023 The Authors. GLIA published by Wiley Periodicals LLC.
All Science Journal Classification (ASJC) codes
- Neurology
- Cellular and Molecular Neuroscience