Abstract
The possible involvement of p53 overproduction in simian virus 40 (SV40)mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced two- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.
Original language | English |
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Pages (from-to) | 3531-3536 |
Number of pages | 6 |
Journal | Molecular and Cellular Biology |
Volume | 6 |
Issue number | 10 |
Publication status | Published - Oct 1986 |
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology