Oxidative stress and therapeutic development in lung cancer

Animesh Chowdhury*, Sarita Sarkar, Soma Ghosh, Ashish Noronha, Tapati Chakraborti, Sajal Chakraborti

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Oxidative stress is associated with the pathogenesis of many lung diseases including lung cancer. The main goal of this chapter is to provide an overview of how reactive oxygen species (ROS) and antioxidants are related to normal physiological function and the pathophysiology of lung cancer and its therapeutic strategies. In this chapter, ROS are first characterized, followed by the role of oxidative stress in progression of different lung cancers, and a brief overview of therapeutic strategies developed gradually over the decades for better therapy of lung cancer is described. Limitations of current strategies and failures of clinical trials have also been discussed, and finally development of new therapy which may be helpful in the treatment of patients with lung cancer has also been addressed as future direction.

Original languageEnglish
Title of host publicationOxidative Stress in Lung Diseases
EditorsSajal Chakraborti, Narasimham L. Parinandi, Rita Ghosh, Nirmal K. Ganguly, Tapati Chakraborti
PublisherSpringer Singapore
Pages427-443
Number of pages17
Volume2
ISBN (Electronic)9789813293663
ISBN (Print)9789813293656
DOIs
Publication statusPublished Online - 24 Nov 2019

Bibliographical note

NA

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine
  • General Health Professions

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