PIP2-the Master Key

Liora Guy-David; Eitan Reuveny

doi:10.1016/j.neuron.2007.08.001

PIP₂-the Master Key

Liora Guy-David, Eitan Reuveny^*

^*Corresponding author for this work

Department of Biomolecular Sciences

Research output: Contribution to journal › Short survey › peer-review

4 Citations (Scopus)

Abstract

The function of inwardly rectifying K⁺ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP₂. In light of these findings and accumulated knowledge, PIP₂ is suggested to have a common coregulatory role in the gating of Kir channels by all their soluble modulators.

Original language	English
Pages (from-to)	537-538
Number of pages	2
Journal	Neuron
Volume	55
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2007.08.001
Publication status	Published - 16 Aug 2007

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2007.08.001

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title = "PIP2-the Master Key",

abstract = "The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2. In light of these findings and accumulated knowledge, PIP2 is suggested to have a common coregulatory role in the gating of Kir channels by all their soluble modulators.",

author = "Liora Guy-David and Eitan Reuveny",

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AU - Guy-David, Liora

AU - Reuveny, Eitan

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AB - The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2. In light of these findings and accumulated knowledge, PIP2 is suggested to have a common coregulatory role in the gating of Kir channels by all their soluble modulators.

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U2 - 10.1016/j.neuron.2007.08.001

DO - 10.1016/j.neuron.2007.08.001

M3 - Short survey

SN - 0896-6273

VL - 55

SP - 537

EP - 538

JO - Neuron

JF - Neuron

IS - 4

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PIP₂-the Master Key

Abstract

All Science Journal Classification (ASJC) codes

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