The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Michal Schwartz; Miguel A. Abellanas; Afroditi Tsitsou-Kampeli; Stefano Suzzi

doi:10.1016/j.neuron.2022.09.007

The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Michal Schwartz^*, Miguel A. Abellanas, Afroditi Tsitsou-Kampeli, Stefano Suzzi

^*Corresponding author for this work

Department of Brain Sciences

Research output: Contribution to journal › Comment/debate › peer-review

23 Citations (Scopus)

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Abstract

Recent functional and anatomical discoveries of brain-immune relationships have overturned previous beliefs regarding the brain's immune privilege. Here, we propose that the brain and immune cells at its borders operate as an “ecosystem” to support the brain's robustness and resilience. Modulation of this ecosystem can be harnessed in the clinic.

Original language	English
Pages (from-to)	3421-3424
Number of pages	4
Journal	Neuron
Volume	110
Issue number	21
DOIs	https://doi.org/10.1016/j.neuron.2022.09.007
Publication status	Published - 2 Nov 2022

Funding

All Science Journal Classification (ASJC) codes

General Neuroscience

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title = "The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases",

abstract = "Recent functional and anatomical discoveries of brain-immune relationships have overturned previous beliefs regarding the brain's immune privilege. Here, we propose that the brain and immune cells at its borders operate as an “ecosystem” to support the brain's robustness and resilience. Modulation of this ecosystem can be harnessed in the clinic.",

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AU - Abellanas, Miguel A.

AU - Tsitsou-Kampeli, Afroditi

AU - Suzzi, Stefano

PY - 2022/11/2

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N2 - Recent functional and anatomical discoveries of brain-immune relationships have overturned previous beliefs regarding the brain's immune privilege. Here, we propose that the brain and immune cells at its borders operate as an “ecosystem” to support the brain's robustness and resilience. Modulation of this ecosystem can be harnessed in the clinic.

AB - Recent functional and anatomical discoveries of brain-immune relationships have overturned previous beliefs regarding the brain's immune privilege. Here, we propose that the brain and immune cells at its borders operate as an “ecosystem” to support the brain's robustness and resilience. Modulation of this ecosystem can be harnessed in the clinic.

UR - https://www.scopus.com/pages/publications/85141889658

U2 - 10.1016/j.neuron.2022.09.007

DO - 10.1016/j.neuron.2022.09.007

M3 - Comment/debate

C2 - 36150394

SN - 0896-6273

VL - 110

SP - 3421

EP - 3424

JO - Neuron

JF - Neuron

IS - 21

ER -

The brain-immune ecosystem: Implications for immunotherapy in defeating neurodegenerative diseases

Abstract

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