The liver by day and by night

Rona Aviram; Gal Manella; Gad Asher

doi:10.1016/j.jhep.2021.01.011

The liver by day and by night

Rona Aviram, Gal Manella, Gad Asher^*

^*Corresponding author for this work

Department of Biomolecular Sciences

Research output: Contribution to journal › Comment/debate › peer-review

11 Citations (Scopus)

Abstract

Circadian clocks oscillate over a period of ≈24 h in light-sensitive organisms and coordinate a wide variety of behavioral, physiological, and molecular functions with geophysical time. In mammals, clocks are present in virtually every cell of the body and function in a cell autonomous and self-sustained manner. The molecular clockwork relies on transcription-translation feedback loops, which generate self-sustained oscillations in the expression levels of the clock components (e.g. PERs, CRYs, CLOCK, BMAL1, NR1D1,2, RORs). These oscillations further control downstream processes through transcriptional and post-transcriptional regulation.

Original language	English
Pages (from-to)	1240-1242
Number of pages	3
Journal	Journal of Hepatology
Volume	74
Issue number	5
Early online date	16 Mar 2021
DOIs	https://doi.org/10.1016/j.jhep.2021.01.011
Publication status	Published - May 2021

Funding

G.A. is supported by the European Research Council (ERC-2017 CIRCOMMUNICATION 770869), Abisch Frenkel Foundation for the Promotion of Life Sciences, Adelis Foundation, Susan and Michael Stern. R.A. is a recipient of the Azrieli Foundation fellowship.

All Science Journal Classification (ASJC) codes

Hepatology

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10.1016/j.jhep.2021.01.011

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title = "The liver by day and by night",

abstract = "Circadian clocks oscillate over a period of ≈24 h in light-sensitive organisms and coordinate a wide variety of behavioral, physiological, and molecular functions with geophysical time. In mammals, clocks are present in virtually every cell of the body and function in a cell autonomous and self-sustained manner. The molecular clockwork relies on transcription-translation feedback loops, which generate self-sustained oscillations in the expression levels of the clock components (e.g. PERs, CRYs, CLOCK, BMAL1, NR1D1,2, RORs). These oscillations further control downstream processes through transcriptional and post-transcriptional regulation.",

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AU - Aviram, Rona

AU - Manella, Gal

AU - Asher, Gad

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AB - Circadian clocks oscillate over a period of ≈24 h in light-sensitive organisms and coordinate a wide variety of behavioral, physiological, and molecular functions with geophysical time. In mammals, clocks are present in virtually every cell of the body and function in a cell autonomous and self-sustained manner. The molecular clockwork relies on transcription-translation feedback loops, which generate self-sustained oscillations in the expression levels of the clock components (e.g. PERs, CRYs, CLOCK, BMAL1, NR1D1,2, RORs). These oscillations further control downstream processes through transcriptional and post-transcriptional regulation.

UR - https://www.scopus.com/pages/publications/85102632776

U2 - 10.1016/j.jhep.2021.01.011

DO - 10.1016/j.jhep.2021.01.011

M3 - Comment/debate

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JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 5

ER -

The liver by day and by night

Abstract

Funding

All Science Journal Classification (ASJC) codes

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