The p53 and Mdm2 families in cancer

Dan Michael, Moshe Oren*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

249 Citations (Scopus)

Abstract

Cells within an organism are occasionally exposed to either intracellular or environmental stress. Such stress often has genotoxic potential that enhances the probability of cancer. Two gene families, the p53 family (p53, p63 and p73) and the Mdm2 family (Mdm2 and MdmX), serve as major integrators of the signals generated by genotoxic and oncogenic stress. Their co-ordinated modulation ensures an optimal response to stress and decreases the likelihood of cancer. Work over the past year has provided better understanding of the p53-Mdm2 module that lies in the heart of this regulatory network, and of the intricate interplay between the various members of the network.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalCurrent opinion in genetics & development
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Feb 2002

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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