The physiological relevance of autophagosome morphogenesis

Oren Shatz; Zvulun Elazar

doi:10.1016/j.tibs.2024.05.002

The physiological relevance of autophagosome morphogenesis

Oren Shatz, Zvulun Elazar^*

^*Corresponding author for this work

Department of Biomolecular Sciences

Research output: Contribution to journal › Short survey › peer-review

Abstract

Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

Original language	English
Pages (from-to)	569-572
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	49
Issue number	7
DOIs	https://doi.org/10.1016/j.tibs.2024.05.002
Publication status	Published Online - 24 May 2024

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

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10.1016/j.tibs.2024.05.002

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title = "The physiological relevance of autophagosome morphogenesis",

abstract = "Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.",

author = "Oren Shatz and Zvulun Elazar",

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T1 - The physiological relevance of autophagosome morphogenesis

AU - Shatz, Oren

AU - Elazar, Zvulun

PY - 2024/5/24

Y1 - 2024/5/24

N2 - Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

AB - Autophagy sequesters cytoplasmic portions into autophagosomes. While selective cargo is engulfed by elongation of cup-shaped isolation membranes (IMs), the morphogenesis of non-selective IMs remains elusive. Based on recent observations, we propose a novel model for autophagosome morphogenesis wherein active regulation of the IM rim serves the physiological roles of autophagy.

UR - http://www.scopus.com/inward/record.url?scp=85193994194&partnerID=8YFLogxK

U2 - 10.1016/j.tibs.2024.05.002

DO - 10.1016/j.tibs.2024.05.002

M3 - Short survey

AN - SCOPUS:85193994194

SN - 0968-0004

VL - 49

SP - 569

EP - 572

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 7

ER -

The physiological relevance of autophagosome morphogenesis

Abstract

All Science Journal Classification (ASJC) codes

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