The role of long-distance mobile metabolites in the plant stress response and signaling

Plants developed sophisticated mechanisms to receive environmental stimuli and generate appropriate signals to maintain optimal growth and stress responses. A fascinating strategy employed by plants is the use of long-distance mobile signals which can trigger local and distant responses across the entire plant. Some metabolites play a central role as long-distance mobile signals allowing plants to communicate across tissues and mount robust stress responses. In the review, we summarize the current state of knowledge regarding the various long-distance mobile metabolites and their function in stress response and signaling pathways. We also raise questions with respect to how can we identify new mobile metabolites and engineer them to improve plant health and resilience.