A microbial iron fist to fight tumors

Samuel P. Nobs; Eran Elinav

doi:10.1038/s41590-024-01806-z

A microbial iron fist to fight tumors

Samuel P. Nobs, Eran Elinav^*

^*Corresponding author for this work

Department of Systems Immunology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

The microbiome is known to affect antitumor immune responses, but how this occurs is unclear. Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce iron sequestration by tumor macrophages, thereby limiting tumor growth and promoting antitumor immunity.

Original language	English
Pages (from-to)	720-721
Number of pages	2
Journal	Nature Immunology
Volume	25
Issue number	5
Early online date	25 Apr 2024
DOIs	https://doi.org/10.1038/s41590-024-01806-z
Publication status	Published - May 2024

Bibliographical note

Publisher Copyright:
© Springer Nature America, Inc. 2024.

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1038/s41590-024-01806-z

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title = "A microbial iron fist to fight tumors",

abstract = "The microbiome is known to affect antitumor immune responses, but how this occurs is unclear. Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce iron sequestration by tumor macrophages, thereby limiting tumor growth and promoting antitumor immunity.",

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AB - The microbiome is known to affect antitumor immune responses, but how this occurs is unclear. Rhamnose-rich polysaccharides (RHP) from a commensal strain of Lactiplantibacillus plantarum have now been shown to induce iron sequestration by tumor macrophages, thereby limiting tumor growth and promoting antitumor immunity.

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M3 - Comment/debate

AN - SCOPUS:85191350297

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VL - 25

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JO - Nature Immunology

JF - Nature Immunology

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ER -

A microbial iron fist to fight tumors

Abstract

Bibliographical note

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